science​

All studies listed used TRT/MTS technology only, unless noted otherwise. Click on the titles to access.

The TRT OrthoGold 100 is a Class I Device with FDA 510(k) clearance for activation of connective tissue, and it is also intended for relief of minor aches and pains.  
The following studies are for informational purposes only and offer insight into mechanisms of action behind the OrthoGold 100's intended purpose. 

Insights  into  Mechanisms  Of  Action  /  experimental  research  (click to Open):

Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Shockwave Therapy Differentially Stimulates Endothelial Cells: Implications on the Control of Inflammation via Toll-Like Receptor 3

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Low Energy Shock Wave Therapy Induces Angiogenesis in Acute Hind-Limb Ischemia via VEGF Receptor 2 Phosphorylation

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: Implications for angiogenesis and vasculogenesis

Effects of Low-energy Shock Waves on Oral Bacteria

UAVA Letter - Nonunion Fracture Successes and Cost Savings

SUBSTANTIAL BIOMECHANICAL IMPROVEMENT BY ESWT AFTER SURGICAL REPAIR OF RODENT CHRONIC ROTATOR CUFF TEARS

Extracorporeal shock wave therapy and shoulder pain

Efficacy of Extracorporeal Shockwave Treatment for male chronic pelvic pain syndrome: a phase III, randomized, doubleEblind placebo controlled study. Preliminary results.

Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy

Accelerated Re-epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

CHRONIC ULCERS: TREATMENT WITH UNFOCUSED EXTRACORPOREAL SHOCK WAVES

Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury

Prophylactic Low Energy ESWT Improves Wound Healing After Vein Harvesting

A therapeutic shock propels Schwann cells to proliferate in peripheral nerve injury

Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction

Current concepts of shockwave therapy in stress fractures

Randomized control of extracorporeal shock wave therapy versus placebo for chronic decubitus ulceration

A new non-surgical method to treat severe burns

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal- Diaphyseal Fractures

Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

ESWT Increases Growth Factor Release from Equine Platelet-Rich Plasma In Vitro

Shock Wave Application to Cell Cultures

Foot Wound Case Study – June 2017

Diabetic Osteomyelitis Foot Case - Oct 2018

Neuropathy Before/After Ex. 1 - March 2019

Neuropathy Before/After Ex. 2 - March 2019

Feeding Tube Chronic Wound Case Study - March 2019

ESWT for wound healing- Technology, mechanisms, and clinical efficacy

SWT Wound Feasibility Study

Shock Wave Therapy Of The Heart

Elucidating the molecular mechanisms underlying cardiac shock wave therapy

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

Angiogenic effect of SWT in Patients with ED

Low-energy Shock Wave Therapy Ameliorates Erectile Dysfunction in a Pelvic Neurovascular Injuries Rat Model

Biologic Principles - Mechanotransduction

Benefits Of Treating Healthy Athletes

Influence of medical shock waves on healthy muscle tissue.

Acoustic stimulation and tropism on skeletal muscles: Tissue resilience & regeneration in sports and ageing

Prospective cohort study examining short term changes in pain after application of Extracorporeal Shockwave Therapy (ESWT) in 178 consecutive patients

Effects of Acoustic Wave Treatment on Aging Patient Balance BEFORE

Effects of Acoustic Wave Treatment on Aging Patient Balance AFTER

The link between shockwaves and innate immunity – the main working mechanism?

ESWT And Nerve Regeneration

ESWt Reduces Neuronal Degeneration Upon Spinal Cord Ischemia and Improves Symptoms in a First-In-Man Trial

ISMST Abstracts 2016

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

Shockwave Medicine and Leprosy The Ultimate Challenge for Skin Regeneration by Mechanotransduction

In-Situ Activation of Penile Progenitor Cells with Li-ESWT

Efficacy of uESWT for Male Chronic Pelvic Pain Syndrome

SoftWave/SparkWave Technology (click for link to MTS, EU)